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mapping interspecific genetic architecture in a host–parasite interaction system


作者單位:Institute of Bioinformatics, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, People‘s Republic of China, 3100291 Corresponding author: Institute of Bioinformatics, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, People‘s Republic of China

【摘要】 under a hypothesis that the host–parasite interaction system is governed by genome-for-genome interaction, we propose a genetic model that integrates genetic information from both the host and parasite genomes. the model can be used for mapping quantitative trait loci (qtl) conferring the interaction between host and parasite and detecting interactions among these qtl. a one-dimensional genome-scan strategy is used to map qtl in both the host and parasite genomes simultaneously conditioned on selected pairs of markers controlling the background genetic variation; a two-dimensional genome-scan procedure is conducted to search for epistasis within the host and parasite genomes and interspecific qtl-by-qtl interactions between the host and parasite genomes. a permutation test is adopted to calculate the empirical threshold to control the experimentwise false-positive rate of detected qtl and qtl interactions. monte carlo simulations were conducted to examine the reliability and the efficiency of the proposed models and methods. simulation results illustrated that our methods could provide reasonable estimates of the parameters and adequate powers for detecting qtl and qtl-by-qtl interactions.

【關鍵詞】 interspecific architecture host–parasite interaction


the interaction between a host and a parasite is a ubiquitous biological phenomenon, which has a significant impact on ecology, evolution, and agriculture. host–parasite interaction drives the coevolution of both the interacting species ( h amilton 1980; t hompson 1994 ). it is believed that host–parasite coevolution has generated much of the biological diversity on the earth ( r ausher 2001 ). processes analogous to the host–parasite coevolution also occur in agricultural systems. when breeders release disease-resistant crop varieties, new virulent pathogen strains will rapidly emerge to overcome the resistance of the crop.

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